Specific genetic modifications of domestic animals by gene targeting and animal cloning

The technology of gene targeting through homologous recombination has been extremely useful for elucidating gene functions in mice. The application of this technology was thought impossible in the large livestock species until the successful creation of the first mammalian clone "Dolly" the sheep. The combination of the technologies for gene targeting of somatic cells with those of animal cloning made it possible to introduce specific genetic mutations into domestic animals. In this review, the principles of gene targeting in somatic cells and the challenges of nuclear transfer using gene-targeted cells are discussed. The relevance of gene targeting in domestic animals for applications in bio-medicine and agriculture are also examined

Experimental implementation of high-fidelity unconventional geometric quantum gates using NMR interferometer

Following a key idea of unconventional geometric quantum computation developed earlier [Phys. Rev. Lett. 91, 197902 (2003)], here we propose a more general scheme in such an intriguing way: $\gamma_{d}=\alpha_{g}+\eta \gamma _{g}$, where $\gamma_{d}$ and $\gamma_{g}$ are respectively the dynamic and geometric phases accumulated in the quantum gate operation, with $\eta$ as a constant and $\alpha_{g}$ being dependent only on the geometric feature of the operation. More arrestingly, we demonstrate the first experiment to implement a universal set of such kind of generalized unconventional geometric quantum gates with high fidelity in an NMR system.Comment: 4 pages, 3 figure

Nonplanar Chiral Metamaterials with Negative Index

We demonstrate experimentally and numerically that nonplanar chiral metamaterials give giant optical activity, circular dichroism, and negative refractive index. The transmission, reflection, and the retrieval results of the experiments agree pretty well with the simulations. This is an important step toward the design and fabrication of three-dimensional isotropic chiral metamaterials.Comment: 3 pages 4 figure